�� Feature Channel: Stem Cells

Curious by Nature: Dr. Gilbert Bernier - Can Stem Cells Cure Blindness?

�� — Fri, 04 Apr 2025 17:50:37 EST

Dr. Gilbert Bernier, a neuroscientist and professor at the University of Montreal who is pushing the boundaries of regenerative medicine.

NK Cells Complexed with Bispecific Antibody Yield High Response Rates in Patients with Lymphoma

University of Texas MD Anderson Cancer Center — Fri, 04 Apr 2025 05:00:00 EST

A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates for patients with refractory CD30-positive lymphomas, according to a new study from The University of Texas MD Anderson Cancer Center.

New Method Creates 854x More Mitochondria, Offering Hope for Cartilage Regeneration

Chinese Academy of Sciences — Mon, 31 Mar 2025 06:10:32 EST

Scientists have unveiled a revolutionary method for mass-producing high-quality human mitochondria, potentially transforming treatments for degenerative diseases. By refining stem cell culture conditions, researchers achieved an extraordinary 854-fold increase in mitochondrial production while significantly enhancing energy output.

Regulation of lncRNA-ENST on Myc-Mediated Mitochondrial Apoptosis in Mesenchymal Stem Cells: In Vitro Evidence Implicated for Acute Lung Injury Therapeutic Potential

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:38 EST

BACKGROUNDAcute lung injury (ALI) is a fatal and heterogeneous disease. While bone marrow mesenchymal stem cells (BMSCs) have shown promise in ALI repair, their efficacy is compromised by a high apoptotic percentage. Preliminary findings ha

Emerging Role of Mesenchymal Stem Cell-Derived Exosomes in the Repair of Acute Kidney Injury

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:25 EST

Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid deterioration in kidney function and has a significant impact on patient health and survival. Mesenchymal stem cells (MSCs) have the potential to enhance renal functi

Fat Mass and Obesity-Associated Protein in Mesenchymal Stem Cells Inhibits Osteoclastogenesis via lnc NORAD/miR-4284 Axis in Ankylosing Spondylitis

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:19 EST

BACKGROUNDAnkylosing spondylitis (AS) is recognized as a long-term inflammatory disorder that leads to inflammation in the spine and joints, alongside abnormal bone growth. In previous studies, we reported that mesenchymal stem cells (MSCs)

Immunomodulatory Effects and Clinical Application of Exosomes Derived From Mesenchymal Stem Cells

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:14 EST

Exosomes (Exos) are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication. They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for the

Cyclodextrin Host-Guest Complex to Facilitate Sinomenine-Based Osteoporosis Therapy

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:12 EST

Xiao et al reported on the natural product sinomenine (SIN), which is a traditional Chinese medicine for treating osteoporosis via its modulation of autophagy; however, SIN was dissolved in dimethyl sulfoxide prior to administration, which

DNA Methyltransferase 1/miR-342-3p/Forkhead box M1 Signaling Axis Promotes Self-Renewal in Cervical Cancer Stem-Like Cells in Vitro and Nude Mice Models

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:11 EST

BACKGROUNDCervical cancer (CC) stem cell-like cells (CCSLCs), defined by the capacity of differentiation and self-renewal and proliferation, play a significant role in the progression of CC. However, the molecular mechanisms regulating thei

MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:06 EST

BACKGROUNDHeart disease remains a leading cause of mortality worldwide, with existing treatments often failing to effectively restore damaged myocardium. Human-induced pluripotent stem cells (hiPSCs) and their derivatives offer promising th

Efficacy Equivalence but Hidden Hurdles: Can Serum-Free Human Umbilical Cord Mesenchymal Stem Cells Translate to Clinically Superior Osteoarthritis Therapy

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:03 EST

This article discusses the study by Xiao et al, which investigated the therapeutic efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) in a mouse model of knee osteoarthritis. The results showed that N-hU

Clinical Experience with Cryopreserved Mesenchymal Stem Cells for Cardiovascular Applications: A Systematic Review

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:02 EST

BACKGROUNDAs living biodrugs, mesenchymal stem cells (MSCs) have progressed to phase 3 clinical trials for cardiovascular applications. However, their limited immediate availability hampers their routine clinical use. AIMTo validate our hy

Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:00 EST

BACKGROUNDMesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics. Differ

NASA Awards NSCF $3.1M to Continue Studying Effects of Microgravity on Brain Cells

National Stem Cell Foundation — Wed, 26 Mar 2025 11:00:59 EST

NASA Awards NSCF $3.1M to Continue Studying Effects of Microgravity on Brain Cells

Scientists Identify Potential New Genetic Target for Sickle Cell Disease Treatment

Johns Hopkins Medicine — Mon, 24 Mar 2025 18:05:38 EST

Scientists from Johns Hopkins Medicine and eight other institutions in the United States, Africa and Europe say they have identified a potential new gene target that could be edited to treat sickle cell disease, an inherited blood disorder marked by sickle-shaped red blood cells that cause intense pain and shorten lifespans.

New Study Reveals Key Protein's Role in Preventing Bone Loss

Chinese Academy of Sciences — Mon, 17 Mar 2025 18:00:12 EST

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. This discovery opens up new possibilities in the fight against bone loss, particularly in postmenopausal osteoporosis.

Stem Cell Trial for Early Alzheimer's Disease Begins at UTHealth Houston

University of Texas Health Science Center at Houston — Fri, 14 Mar 2025 10:15:52 EST

A stem cell therapy trial aimed at reducing neuroinflammation in patients with presymptomatic Alzheimer's disease is underway at UTHealth Houston.

Children's Hospital of Philadelphia Preclinical Study Demonstrates Improved Gene Therapy Approach to Treating Metachromatic Leukodystrophy

Children's Hospital of Philadelphia — Tue, 11 Mar 2025 19:20:06 EST

In a preclinical study, researchers at Children's Hospital of Philadelphia (CHOP) demonstrated a novel gene therapy with potentially increased effectiveness and safety for the treatment for metachromatic leukodystrophy (MLD), a rare disease in young children characterized by the deficient activity of a critical enzyme.

VUMC Part of New Study Validating Curative Therapy for Sickle Cell Disease

Vanderbilt University Medical Center — Tue, 04 Mar 2025 10:50:20 EST

A modified bone marrow transplant procedure for sickle cell disease (SCD) co-developed at Vanderbilt University Medical Center, Johns Hopkins University School of Medicine, and the University of California, San Francisco, can cure the disease, a new study has found.

Research Tip Sheet: New Single-Cell Proteomics Technology Reveals Heart Cell Differences

Cedars-Sinai — Tue, 04 Mar 2025 04:00:20 EST

A multidisciplinary team of Cedars-Sinai investigators has used a novel single-cell proteomics approach to better understand the differences between naturally occurring adult heart cells and heart cells derived from induced pluripotent stem cells.

�������� Feature Channel: Stem Cells

Curious by Nature: Dr. Gilbert Bernier - Can Stem Cells Cure Blindness?

NK Cells Complexed with Bispecific Antibody Yield High Response Rates in Patients with Lymphoma

New Method Creates 854x More Mitochondria, Offering Hope for Cartilage Regeneration

Regulation of lncRNA-ENST on Myc-Mediated Mitochondrial Apoptosis in Mesenchymal Stem Cells: In Vitro Evidence Implicated for Acute Lung Injury Therapeutic Potential

Emerging Role of Mesenchymal Stem Cell-Derived Exosomes in the Repair of Acute Kidney Injury

Fat Mass and Obesity-Associated Protein in Mesenchymal Stem Cells Inhibits Osteoclastogenesis via lnc NORAD/miR-4284 Axis in Ankylosing Spondylitis

Immunomodulatory Effects and Clinical Application of Exosomes Derived From Mesenchymal Stem Cells

Cyclodextrin Host-Guest Complex to Facilitate Sinomenine-Based Osteoporosis Therapy

DNA Methyltransferase 1/miR-342-3p/Forkhead box M1 Signaling Axis Promotes Self-Renewal in Cervical Cancer Stem-Like Cells in Vitro and Nude Mice Models

MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model

Efficacy Equivalence but Hidden Hurdles: Can Serum-Free Human Umbilical Cord Mesenchymal Stem Cells Translate to Clinically Superior Osteoarthritis Therapy

Clinical Experience with Cryopreserved Mesenchymal Stem Cells for Cardiovascular Applications: A Systematic Review

Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia

NASA Awards NSCF $3.1M to Continue Studying Effects of Microgravity on Brain Cells

Scientists Identify Potential New Genetic Target for Sickle Cell Disease Treatment

New Study Reveals Key Protein's Role in Preventing Bone Loss

Stem Cell Trial for Early Alzheimer's Disease Begins at UTHealth Houston

Children's Hospital of Philadelphia Preclinical Study Demonstrates Improved Gene Therapy Approach to Treating Metachromatic Leukodystrophy

VUMC Part of New Study Validating Curative Therapy for Sickle Cell Disease

Research Tip Sheet: New Single-Cell Proteomics Technology Reveals Heart Cell Differences

�� Feature Channel: Stem Cells