Researchers have identified a critical amino acid transporter, SlAAP6, that enhances tomato growth and salt tolerance by mediating the uptake and distribution of branched-chain amino acids (BCAAs). Overexpressing SlAAP6 elevated BCAA levels, boosted plant biomass, and improved stress resistance, while knockout mutants exhibited stunted growth and heightened salt sensitivity.
Here鈥檚 a look at some of the most recent discoveries that are helping to advance more effective and targeted treatment strategies for glioblastoma and other aggressive brain cancers.
Two years after receiving an investigational gene therapy as part of a clinical trial co-led by UCLA鈥檚 Dr. Donald Kohn, nine children born with a life-threatening immune disorder are living free of disease symptoms.
In a rare collaboration with geneticists and archaeologists, a federally recognized tribe in the United States has utilized ancient DNA to establish a genetic link to an important ancestral heritage site, Pueblo Bonito in Chaco Canyon.
Fruit firmness plays a critical role in apple quality, influencing both shelf life and consumer preference. Scientists have now identified a natural genetic variation in the MdNAC5 gene that governs differences in apple firmness and ripening speed. By resequencing hundreds of apple hybrids, researchers mapped a key genetic locus and pinpointed a single A-to-T mutation that affects fruit texture. Functional experiments showed that different MdNAC5 variants distinctly regulate ethylene biosynthesis, a central pathway in fruit softening. This discovery offers new insights into the genetic control of apple ripening and opens up potential strategies for breeding apples with optimized firmness and storage properties.
A new liquid biopsy approach developed by聽Johns Hopkins Kimmel Cancer Center investigators could revolutionize brain cancer detection by identifying circulating DNA fragments from tumors and immune cells in blood samples, potentially enabling earlier diagnosis.
Metabolon Launches Microbiome Research Solution Combining New Microbiome Panel, Metagenomics Sequencing, and Multiomics Bioinformatics Tools
Nabsys 2.0, LLC (Nabsys), a pioneer in electronic genome mapping technology, announces its achievement of ISO 9001:2015 certification. This internationally recognized standard demonstrates Nabsys' dedication to maintaining a robust and effective quality management system.
Researchers have uncovered multiple new genes and genetic pathways that could lead to repurposing hundreds of existing drugs for osteoarthritis, the most common form of arthritis.
How did horses become some of the greatest athletes in the animal kingdom? Researchers at Johns Hopkins Medicine may have found the answer, pinpointing a genetic mutation and evolutionary process that occurred millions of years ago, which appears to have optimized horses鈥� speeds and stamina.
鈥� RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors 鈥� Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors 鈥� This class of drugs is important because many solid tumor patients with microsatellite instability (MSI) do not benefit from currently approved immunotherapies 鈥� Encouraging early results in this first-in-human trial prompted additional trial cohorts to optimize recommended dose for future clinical development
鈥� Combining Lynparza (olaparib) and Keytruda (pembrolizumab) showed antitumor activity in multiple cancer types, particularly those with BRCA1/2 mutations 鈥� Combination demonstrated complete responses and partial responses in different cancer types, including those beyond the currently approved indications for these therapies
A recent study has revealed that KIAA1199, a secreted protein produced by bone marrow cells, plays a crucial role in regulating both fat formation and overall energy metabolism. The protein's impact extends beyond bone remodeling, influencing glucose and lipid metabolism. Mice lacking KIAA1199 showed reduced fat mass, improved insulin sensitivity, and a decreased risk of obesity-related diseases. These findings suggest that targeting KIAA1199 could lead to new therapeutic strategies for combating metabolic disorders like obesity and type 2 diabetes.
Wren Laboratories, a leader in molecular diagnostics, is proud to announce that its breakthrough liquid biopsy test, PROSTest鈩�, has been approved by the New York State Department of Health Clinical Laboratory Evaluation Program (NYSDOH-CLEP).
Over 20 scientists from the Monell Chemical Senses Center will present their latest research at the 47th Association for Chemoreception Sciences annual conference, which covers the latest advances in the fields of taste, smell, and related chemical senses. Monell researchers are chairing and participating in oral presentation sessions as well as sharing close to 20 posters over three days. Several Monellians will also receive annual awards from AChemS for their research achievements, highlighted below.
Researchers at Mayo Clinic's Center for Individualized Medicine have discovered a rare genetic variant that can directly cause metabolic dysfunction-associated steatotic liver disease, formerly known as nonalcoholic fatty liver disease.
An international team led by the University of California San Diego has identified a potential microbial culprit behind the alarming rise in early-onset colorectal cancer: a bacterial toxin called colibactin.
A team of researchers has used advanced DNA sequencing to develop the most comprehensive atlas yet of genetic change through generations, laying the foundations for new insights into the roots of human disease and evolution.
ProBio, a global contract development and manufacturing organization (CDMO), announced that it will present six poster presentations at the American Society of Gene and Cell Therapy (ASGCT) 28th Annual Meeting, taking place May 13鈥�15, 2025, in New Orleans, LA.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal 海角社区 keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right