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A large-scale study in which UdeM cardiologist Rafik Tadros took part focuses on the origins of hypertrophic cardiomyopathy, or HCM.

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In a groundbreaking study on the synthesis of cellulose 鈥� a major constituent of all plant cell walls 鈥� a team of Rutgers University-New Brunswick researchers has captured images of the microscopic process of cell-wall building continuously over 24 hours with living plant cells, providing critical insights that may lead to the development of more robust plants for increased food and lower-cost biofuels production.

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Researchers at the National Institutes of Health (NIH) have developed eye drops that extend vision in animal models of a group of inherited diseases that lead to progressive vision loss in humans, known as retinitis pigmentosa.

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A research team investigates how genome editing can be harnessed to accelerate cassava breeding and improve key traits.

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A research team using EST-SSR molecular marker technology reveals vital information on the genetic diversity and structure of nine natural populations of Phoebe bournei, providing a scientific foundation for the conservation and sustainable use of its germplasm resources.

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An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma. They found that the drug, already FDA-approved for certain adult cancers, was generally safe and resulted in tumor reduction visible on brain scans, as well as clinical improvement, in 3 out of 7 patients.

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Researchers have shed new light on how a type of heart valve disease鈥攁ortic valve stenosis鈥攑rogresses differently in males and females. The research paves the way for treatments that can be tailored to a patient's biological sex.

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A new study by Mayo Clinic Comprehensive Cancer Center researchers found that the presence of a specific genetic mutation 鈥� KRAS circulating tumor DNA (ctDNA) 鈥� strongly indicates a higher risk of cancer spread and worse survival rates for patients with pancreatic ductal adenocarcinoma (PDAC). The mutation was identified using a readily available and clinically approved blood and abdominal fluid test.

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鈥淭hese one-year incubator grants attract much-needed brainpower to the field of glaucoma and move us ever closer to the discovery of new treatments to preserve and restore vision.鈥�

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Experts in nutrition science from across the University of Miami offer their thoughts on some of the best foods to help us ward off chronic disease.

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Scientists at Washington University School of Medicine in St. Louis and the Perelman School of Medicine at the University of Pennsylvania have identified a key component to launching immune activity 鈥� and overactivity. The researchers identified a protein in cells that spurs the release of infection-fighting molecules. The protein, whose role in the immune system had not previously been suspected, provides a potential target for therapies that could prevent overreactive immune responses that are at the root of several debilitating illnesses.

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New RNA-based active agents reliably protect plants against the Cucumber mosaic virus, the most common virus in agriculture and horticulture. They were developed by researchers at the Martin Luther University Halle-Wittenberg. In lab experiments, almost all of the treated plants survived an infection. The study will appear in "Nucleic Acids Research".

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A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration (IDD), a primary cause of chronic lower back pain. Researchers discovered that FSP1, when upregulated by the inflammatory cytokine TNF伪, accelerates disc degeneration through caspase 3-dependent apoptosis and mitochondrial damage. This finding positions FSP1 as a promising therapeutic target for IDD, potentially offering relief to millions suffering from persistent back pain.

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A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of hypospadias, a common congenital malformation affecting male urethral development. The research reveals that MAFB and CCAAT/enhancer-binding protein alpha (CEBPA) regulate urothelial cell growth via the Wnt/尾-catenin signaling pathway, offering new insights into the genetic mechanisms underlying this condition. These findings pave the way for innovative therapeutic strategies and a deeper understanding of the genetic and molecular foundations of hypospadias.

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Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature Communications showing that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like cells to spew inflammatory molecules that can contribute to chronic inflammation in the body.

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Researchers at Case Western Reserve University have discovered molecules that present the potential to drive the development of gastric cancer鈥攁mong the world鈥檚 deadliest forms of the disease.

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Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as heart, skin or liver tissue. Scientists at St. Jude and the University of Wisconsin-Madison today share a generative algorithm for achieving both high genome and image resolution.

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Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair, or NER. They built a computer model of a critical NER component called the pre-incision complex, or PInC, which plays a key role in regulating DNA repair processes in the latter stages of the NER pathway. Decoding NER鈥檚 sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.

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Haselkorn was widely known for his work on plant viral RNA, and was highly regarded for his teaching and mentoring with students.

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A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common congenital condition that affects male children. The research highlights how SOX9 regulates critical molecular pathways involved in urethral development, including the Wnt/尾-catenin signaling pathway and epithelial-mesenchymal transition (EMT). The study reveals that reduced SOX9 expression leads to impaired EMT and abnormal Wnt signaling in tissues affected by hypospadias. These findings provide new insights into the condition's molecular underpinnings, potentially paving the way for innovative, targeted therapies.